PubMed ID:
17684132
Public Release Type:
Journal
Publication Year: 2007
Affiliation: New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA. shall@nerisicience.com
DOI:
https://doi.org/10.1158/1055-9965.EPI-07-0306
Authors:
Hall SA,
Link CL,
McKinlay JB,
Montgomery RB,
Page ST,
Travison TG
Studies:
Boston Area Community Health Survey
In 2005, statins were among the most commonly used prescription medications in the United States. Some data suggest statins may affect cancer risk and/or disease severity. Because cholesterol is a required intermediate in sex steroid synthesis, it is possible that statins influence prostate cancer risk through effects on steroid hormone metabolism. We investigated whether levels of circulating androgens and their carrier protein, sex hormone-binding globulin (SHBG), varied by statin exposure among a sample of 1,812 men from a population-based epidemiologic study, the Boston Area Community Health Survey.