An official website of the United States government
Publication Information
Affiliation
Institute of Evolution, University of Haifa, Haifa, Israel.
Authors
Brodsky LI, Li J, Tavis JE, Taylor MW, Tsukahara T, Wahed AS
Studies
Citation
Brodsky LI, Wahed AS, Li J, Tavis JE, Tsukahara T, Taylor MW. A novel unsupervised method to identify genes important in the anti-viral response: application to interferon/ribavirin in hepatitis C patients. PLoS One 2007 Jul 4;2(7):e584.Abstract
Treating hepatitis C with interferon/ribavirin results in a varied response in terms of decrease in viral titer and ultimate outcome. Marked responders have a sharp decline in viral titer within a few days of treatment initiation, whereas in other patients there is no effect on the virus (poor responders). Previous studies have shown that combination therapy modifies expression of hundreds of genes in vitro and in vivo. However, identifying which, if any, of these genes have a role in viral clearance remains challenging.