PubMed ID:
17589564
Public Release Type:
Journal
Publication Year: 2007
Affiliation: Institute of Evolution, University of Haifa, Haifa, Israel.
DOI:
https://doi.org/10.1371/journal.pone.0000584
Authors:
Brodsky LI,
Li J,
Tavis JE,
Taylor MW,
Tsukahara T,
Wahed AS
Studies:
Viral Resistance to Antiviral Therapy of Chronic Hepatitis C
Treating hepatitis C with interferon/ribavirin results in a varied response in terms of decrease in viral titer and ultimate outcome. Marked responders have a sharp decline in viral titer within a few days of treatment initiation, whereas in other patients there is no effect on the virus (poor responders). Previous studies have shown that combination therapy modifies expression of hundreds of genes in vitro and in vivo. However, identifying which, if any, of these genes have a role in viral clearance remains challenging.