NIDDK Central Repository - Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease.

An official website of the United States government

NIDDK Central Repository

Publication Information

DOI

10.1016/j.cgh.2007.02.017

PubMed ID

17509943

Public Release Type

Journal

Publication Year

2007

Affiliation

Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, California 94304, USA.

Authors

Brant SR, Cho JH, Duerr RH, Kamal A, Kugathasan S, Madani ND, Omary MB, Strnad P, Tao GZ, Zhang L, Zhou Q

Studies

IBD

Citation

Tao GZ, Strnad P, Zhou Q, Kamal A, Zhang L, Madani ND, Kugathasan S, Brant SR, Cho JH, Omary MB, Duerr RH. Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. Clin Gastroenterol Hepatol 2007 Jul;5(7):857-64. Epub 2007 May 16.

Abstract

Keratin-8 (KRT8)-null mice develop spontaneous colitis and predisposition to liver injury. Human studies show that some KRT8 variants predispose to end-stage liver disease and progression and suggest that such variants might associate with UC or CD. We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD.