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PubMed ID:
17509943
Public Release Type:
Journal
Publication Year: 2007
Affiliation: Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, California 94304, USA.
DOI:
https://doi.org/10.1016/j.cgh.2007.02.017
Authors:
Tao GZ,
Strnad P,
Zhou Q,
Kamal A,
Zhang L,
Madani ND,
Kugathasan S,
Brant SR,
Cho JH,
Omary MB,
Duerr RH
Studies:
Inflammatory Bowel Disease Genetics
Keratin-8 (KRT8)-null mice develop spontaneous colitis and predisposition to liver injury. Human studies show that some KRT8 variants predispose to end-stage liver disease and progression and suggest that such variants might associate with UC or CD. We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD.
