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Publication Information
Affiliation
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Authors
Abecasis GR, Bark CW, Barnhart MW, Bergman RN, Boehnke M, Bonnycastle LL, Buchanan TA, Chines PS, Collins FS, Conneely KN, Ding CJ, Doheny KF, Duren WL, Erdos MR, Goldstein JL, Hetrick KN, Hu T, Jackson AU, Kinnunen L, Li XY, Li Y, Mohlke KL, Narisu N, Prokunina-Olsson L, Pruim R, Pugh EW, Riebow NL, Saramies J, Scott LJ, Sprau AG, Stringham HM, Swift AJ, Tong M, Tuomilehto J, Valle TT, Watanabe RM, Watkins L, White PP, Willer CJ, Xiang F, Xiao R
Studies
Citation
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007 Jun 1;316(5829):1341-5. Epub 2007 Apr 26.Abstract
Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs. We carried out association analysis with these SNPs to identify genetic variants that predispose to T2D, compared our T2D association results with the results of two similar studies, and genotyped 80 SNPs in an additional 1215 Finnish T2D cases and 1258 Finnish NGT controls. We identify T2D-associated variants in an intergenic region of chromosome 11p12, contribute to the identification of T2D-associated variants near the genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk. This brings the number of T2D loci now confidently identified to at least 10.