PubMed ID:
16964546
Public Release Type:
Journal
Publication Year: 2006
Affiliation: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8887, USA. William.Lee@utsouthwestern.edu
DOI:
https://doi.org/10.1007/s10620-005-9061-5
Authors:
Lee WM,
Acute Liver Failure Study Group,
Brown KE,
Davern T,
Dawson GJ,
Fontana R,
Gutierrez RA,
Lalani E,
Rossaro L,
Schlauder GG,
Young NS
Studies:
Acute Liver Failure Study Group: Adult Acute Liver Failure Study
Viral hepatitis A and B are known to cause acute liver failure. While nearly 20% of acute liver failure cases are of indeterminate etiology, screening for other viruses has not been uniformly performed. We looked for evidence for parvovirus B19 and hepatitis E virus in sera from U.S. acute liver failure patients. For B19, 78 patients' sera, including 34 with indeterminate etiology, were evaluated by DNA dot-blot hybridization, reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay for immunoglobin G and M antibodies; none showed evidence for infection.