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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2006
Affiliation
Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, USA. jameslaurap@uams.edu
Authors
Alonso EM, Davern TJ, Hinson JA, Hynan LS, James LP, Lee WM, Pediatric Acute Liver Failure Study Group, Squires RH
Studies
Citation
James LP, Alonso EM, Hynan LS, Hinson JA, Davern TJ, Lee WM, Squires RH, Pediatric Acute Liver Failure Study Group. Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Pediatrics 2006 Sep;118(3):e676-81.

Abstract

Acetaminophen cysteine protein adducts are a widely recognized correlate of acetaminophen-mediated hepatic injury in laboratory animals. The objective of this study was to use a new assay for the detection of acetaminophen cysteine protein adducts in children with acute liver failure to determine the role of acetaminophen toxicity in acute liver failure of unknown cause.