PubMed ID:
16950959
Public Release Type:
Journal
Publication Year: 2006
Affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, USA. jameslaurap@uams.edu
DOI:
https://doi.org/10.1542/peds.2006-0069
Authors:
Lee WM,
Alonso EM,
Davern TJ,
Hinson JA,
Hynan LS,
James LP,
Pediatric Acute Liver Failure Study Group,
Squires RH
Studies:
Pediatric Acute Liver Failure
Acetaminophen cysteine protein adducts are a widely recognized correlate of acetaminophen-mediated hepatic injury in laboratory animals. The objective of this study was to use a new assay for the detection of acetaminophen cysteine protein adducts in children with acute liver failure to determine the role of acetaminophen toxicity in acute liver failure of unknown cause.