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Publication Information
Affiliation
Center for Inflammatory Bowel Disease, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Authors
Achkar JP, Barmada MM, Bayless TM, Brant SR, Bromfield GP, Cho JH, Cohen Z, Dassopoulos T, Datta LW, Duerr RH, Griffiths AM, Hanauer SB, McLeod RS, Nicolae DL, Reddy D, Rioux JD, Schumm P, Silverberg MS, Siminovitch K, Steinhart AH, Tuvlin JA, Yang H, Zhang L
Studies
Citation
Achkar JP, Dassopoulos T, Silverberg MS, Tuvlin JA, Duerr RH, Brant SR, Siminovitch K, Reddy D, Datta LW, Bayless TM, Zhang L, Barmada MM, Rioux JD, Steinhart AH, McLeod RS, Griffiths AM, Cohen Z, Yang H, Bromfield GP, Schumm P, Hanauer SB, Cho JH, Nicolae DL. Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus. Am J Gastroenterol 2006 Mar;101(3):572-80.Abstract
The complete elucidation of genetic variants that contribute to inflammatory bowel disease (IBD) will likely include variants that increase risk to both Crohn's disease and ulcerative colitis as well as variants that increase risk for particular phenotypic subsets. The purpose of this study was to assess phenotypic subsets that contribute to the major IBD susceptibility loci.