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Publication Information
Affiliation
University of California at San Francisco, San Francisco, California, USA. timothy.davern@ucsf.edu [corrected]
Authors
Acute Liver Failure Study Group, Davern TJ 2nd, Fontana RJ, Hinson JA, James LP, Lalani E, Larson AM, Lee WM, Munoz S, Polson J, Shakil AO
Studies
Citation
Davern TJ 2nd, James LP, Hinson JA, Polson J, Larson AM, Fontana RJ, Lalani E, Munoz S, Shakil AO, Lee WM, Acute Liver Failure Study Group. Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology 2006 Mar;130(3):687-94.Abstract
Acetaminophen toxicity is the most common cause of acute liver failure (ALF) in the United States and Great Britain, but may be underrecognized in certain settings. Acetaminophen-protein adducts are specific biomarkers of drug-related toxicity in animal models and can be measured in tissue or blood samples. Measurement of serum adducts might improve diagnostic accuracy in acute liver failure (ALF) patients.