PubMed ID:
16530510
Public Release Type:
Journal
Publication Year: 2006
Affiliation: University of California at San Francisco, San Francisco, California, USA. timothy.davern@ucsf.edu [corrected]
DOI:
https://doi.org/10.1053/j.gastro.2006.01.033
Authors:
Fontana RJ,
Lee WM,
Acute Liver Failure Study Group,
Davern TJ 2nd,
Hinson JA,
James LP,
Lalani E,
Larson AM,
Munoz S,
Polson J,
Shakil AO
Studies:
Acute Liver Failure Study Group: Adult Acute Liver Failure Study
Acetaminophen toxicity is the most common cause of acute liver failure (ALF) in the United States and Great Britain, but may be underrecognized in certain settings. Acetaminophen-protein adducts are specific biomarkers of drug-related toxicity in animal models and can be measured in tissue or blood samples. Measurement of serum adducts might improve diagnostic accuracy in acute liver failure (ALF) patients.