NIDDK Central Repository - The TGF-beta 1 gene codon 10 polymorphism contributes to the genetic predisposition to nephropathy in Type 1 diabetes.

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NIDDK Central Repository

Publication Information

DOI

10.1111/j.1464-5491.2005.01376.x

PubMed ID

15606694

Public Release Type

Journal

Publication Year

2005

Affiliation

Division of Medical Sciences, University of Birmingham, Birmingham Heartlands Hospital, UK. ashpat100@hotmail.com

Authors

Bain SC, Barnett AH, Gill GV, Lympany PA, Patel A, Rippin JD, Scott WR, Warren 3/UK GoKind Study Group

Studies

GoKinD

Citation

Patel A, Scott WR, Lympany PA, Rippin JD, Gill GV, Barnett AH, Bain SC, Warren 3/UK GoKind Study Group. The TGF-beta 1 gene codon 10 polymorphism contributes to the genetic predisposition to nephropathy in Type 1 diabetes. Diabet Med 2005 Jan;22(1):69-73.

Abstract

We hypothesize that transforming growth factor-beta (TGF-beta), a multifunctional growth factor which plays a key role in the development of tissue fibrosis, may be involved in the pathophysiology of diabetic nephropathy. Our aim was to examine three polymorphisms within the TGF-beta 1 gene, in codons 10, 25 and 263, for association with nephropathy in Type 1 diabetes.