PubMed ID:
15200451
Public Release Type:
Journal
Publication Year: 2004
Affiliation: Division of Nephrology; and Division of Biostatistics and Clinical Care Research, Tufts-New England Medical Center, Boston, Massachusetts, USA.
DOI:
https://doi.org/10.1111/j.1523-1755.2004.00748.x
Authors:
Tighiouart H,
Balakrishnan VS,
Guo D,
HEMO Study Group,
Jaber BL,
Pereira BJ,
Rao M
Studies:
Hemodialysis Study
Atherosclerotic vascular disease is a leading cause of morbidity and mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD). Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that inhibits the atheromatous process. We studied coding region polymorphisms of the TGF-beta1 gene (+869 T --> C at codon 10 and +915 G --> C at codon 25) as genetic susceptibility factors for prevalent vascular disease and cardiac outcomes in a cohort of HD patients enrolled in the HEMO Study.