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Publication Information
PubMed ID
Public Release Type
Journal
Publication Year
2004
Affiliation
Division of Nephrology; and Division of Biostatistics and Clinical Care Research, Tufts-New England Medical Center, Boston, Massachusetts, USA.
Authors
Balakrishnan VS, Guo D, HEMO Study Group, Jaber BL, Pereira BJ, Rao M, Tighiouart H
Studies
Citation
Rao M, Guo D, Jaber BL, Tighiouart H, Pereira BJ, Balakrishnan VS, HEMO Study Group. Transforming growth factor-beta 1 gene polymorphisms and cardiovascular disease in hemodialysis patients. Kidney Int 2004 Jul;66(1):419-27.Abstract
Atherosclerotic vascular disease is a leading cause of morbidity and mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD). Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that inhibits the atheromatous process. We studied coding region polymorphisms of the TGF-beta1 gene (+869 T --> C at codon 10 and +915 G --> C at codon 25) as genetic susceptibility factors for prevalent vascular disease and cardiac outcomes in a cohort of HD patients enrolled in the HEMO Study.