NIDDK Central Repository - Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients.

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NIDDK Central Repository

Publication Information

DOI

10.1046/j.1523-1755.2003.00721.x

PubMed ID

12472798

Public Release Type

Journal

Publication Year

2003

Affiliation

Department of Medicine, and Department of Statistics, University of California, Davis, California 95616, USA. gakaysen@ucdavis.edu

Authors

Dubin JA, HEMO Group, Kaysen GA, Levin NW, Mitch WE, Müller HG, Rosales L

Studies

HEMO

Citation

Kaysen GA, Dubin JA, Müller HG, Mitch WE, Rosales L, Levin NW, HEMO Group. Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients. Kidney Int 2003 Jan;63(1):315-22.

Abstract

Fibrinogen is a risk factor for cardiovascular disease. It also is an acute phase protein (APP) and its plasma concentration increases with inflammation. Fibrinogen synthesis correlates with albumin synthesis in nephrotic patients and in patients with an expanded plasma volume even when serum albumin is normal and there is no inflammatory disease. The relationships among albumin synthesis, the acute phase response and plasma fibrinogen levels in hemodialysis patients are unknown.