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Publication Information
Affiliation
Department of Medicine, and Department of Statistics, University of California, Davis, California 95616, USA. gakaysen@ucdavis.edu
Authors
Dubin JA, HEMO Group, Kaysen GA, Levin NW, Mitch WE, Müller HG, Rosales L
Studies
Citation
Kaysen GA, Dubin JA, Müller HG, Mitch WE, Rosales L, Levin NW, HEMO Group. Impact of albumin synthesis rate and the acute phase response in the dual regulation of fibrinogen levels in hemodialysis patients. Kidney Int 2003 Jan;63(1):315-22.Abstract
Fibrinogen is a risk factor for cardiovascular disease. It also is an acute phase protein (APP) and its plasma concentration increases with inflammation. Fibrinogen synthesis correlates with albumin synthesis in nephrotic patients and in patients with an expanded plasma volume even when serum albumin is normal and there is no inflammatory disease. The relationships among albumin synthesis, the acute phase response and plasma fibrinogen levels in hemodialysis patients are unknown.