PubMed ID:
11832527
Public Release Type:
Journal
Publication Year: 2002
Affiliation: Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd., Suite 750, Rockville, MD 20852, USA.
DOI:
https://doi.org/10.1056/NEJMoa012512
Authors:
Knowler WC,
Barrett-Connor E,
Diabetes Prevention Program Research Group,
Fowler SE,
Hamman RF,
Lachin JM,
Nathan DM,
Walker EA
Studies:
Diabetes Prevention Program
,
Diabetes Prevention Program Outcomes Study
Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible. We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes.