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Publication Information
Affiliation
Division of Nephrology Department of Medicine, University of California, Davis 95616, USA. gakaysen@ucdavis.edu
Authors
Dubin JA, HEMO Group, Kaysen GA, Levin NW, Mitch WE, Müller HG
Studies
Citation
Kaysen GA, Dubin JA, Müller HG, Mitch WE, Levin NW, HEMO Group. Levels of alpha1 acid glycoprotein and ceruloplasmin predict future albumin levels in hemodialysis patients. Kidney Int 2001 Dec;60(6):2360-6.Abstract
Serum albumin concentration predicts mortality in hemodialysis (HD) patients. While serum albumin concentration correlates with serum concentration of C-reactive protein (CRP) and is dependent upon CRP in multiple regression models in cross sectional studies, CRP does not predict future albumin levels, possibly because CRP changes rapidly, yielding large month-to-month variability in CRP. If inflammation causes rather than is simply associated with hypoalbuminemia, then changes in the levels of acute phase proteins should precede changes in serum albumin concentration.