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PubMed ID:
1664792
Public Release Type:
Journal
Publication Year: 1991
Affiliation: Department of Biostatistics and Epidemiology, Cleveland Clinic Foundation, Ohio 44195-5196.
DOI:
https://doi.org/10.1016/0197-2456(91)90069-x
Authors:
Beck GJ,
Schluchter MD,
Williams GW,
Hunsicker LG,
Gassman JJ,
Coggins CH,
Berg RL
Studies:
Modification of Diet in Renal Disease
The Modification of Diet in Renal Disease Trial is a multicenter randomized clinical trial for men and women aged 18-70 years with chronic renal disease who are not on dialysis and who have not had a kidney transplant. Study participants are randomized in a 2 x 2 factorial design to diets containing different amounts of protein and phosphorus and to two levels of blood pressure control. The prescribed modifications differ depending on the level of a patient's kidney function. The primary outcome variable to compare diet or blood pressure groups is each patient's slope (or the change) in glomerular filtration rate with time. This paper describes the study design with particular emphasis on sample size determination. Special statistical analysis issues that arise with slope as the outcome are also discussed.
