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Publication Information
Authors
Andlauer Till F. M., Link Jenny, Martin Dorothea, Ryner Malin, Hermanrud Christina, Grummel Verena, Auer Michael, Hegen Harald, Aly Lilian, Gasperi Christiane, Knier Benjamin, Müller-Myhsok Bertram, Jensen Poul Erik Hyldgaard, Sellebjerg Finn, Kockum Ingrid, Olsson Tomas, Pallardy Marc, Spindeldreher Sebastian, Deisenhammer Florian, Fogdell-Hahn Anna, Hemmer Bernhard
Studies
Abstract
Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a genetic predisposition exists. Here, we present a genome-wide association study on ADA and predict the occurrence of antibodies in multiple sclerosis patients treated with different interferon β preparations.