An official website of the United States government
This repository is under review for potential modification in compliance with Administration directives.
Publication Information
Authors
Huang Chengrui, Haritunians Talin, Okou David T., Cutler David J., Zwick Michael E., Taylor Kent D., Datta Lisa W., Maranville Joseph C., Liu Zhenqiu, Ellis Shannon, Chopra Pankaj, Alexander Jonathan S., Baldassano Robert N., Cross Raymond K., Dassopoulos Themistocles, Dhere Tanvi A., Duerr Richard H., Hanson John S., Hou Jason K., Hussain Sunny Z., Isaacs Kim L., Kachelries Kelly E, Kader Howard, Kappelman Michael D., Katz Jeffrey, Kellermayer Richard, Kirschner Barbara S., Kuemmerle John F., Kumar Archana, Kwon John H., Lazarev Mark, Mannon Peter, Moulton Dedrick E., Osuntokun Bankole O., Patel Ashish, Rioux John D., Rotter Jerome I., Saeed Shehzad, Scherl Ellen J., Silverberg Mark S., Silverman Ann, Targan Stephan R., Valentine John F., Wang Ming-Hsi, Simpson Claire L., Bridges S. Louis, Kimberly Robert P., Rich Stephen S., Cho Judy H., Rienzo Anna Di, Kao Linda W.H., McGovern Dermot P.B., Brant Steven R., Kugathasan Subra
Studies
Abstract
Inflammatory bowel disease (IBD) has familial aggregation in African Americans (AAs), but little is known about the molecular genetic susceptibility. Mapping studies using the Immunochip genotyping array expand the number of susceptibility loci for IBD in Caucasians to 163, but the contribution of the 163 loci and European admixture to IBD risk in AAs is unclear. We performed a genetic mapping study using the Immunochip to determine whether IBD susceptibility loci in Caucasians also affect risk in AAs and identify new associated loci.