An official website of the United States government
This repository is under review for potential modification in compliance with Administration directives.
Publication Information
Authors
Venkateswaran Suresh, Prince Jarod, Cutler David J, Marigorta Urko M, Okou David T, Prahalad Sampath, Mack David, Boyle Brendan, Walters Thomas, Griffiths Anne, Sauer Cary G, LeLeiko Neal, Keljo David, Markowitz James, Baker Susan S, Rosh Joel, Pfefferkorn Marian, Heyman Melvin B, Patel Ashish, Otley Anthony, Baldassano Robert, Noe Joshua, Rufo Paul, Oliva-Hemker Maria, Davis Sonia, Zwick Michael E, Gibson Greg, Denson Lee A, Hyams Jeffrey, Kugathasan Subra
Studies
Abstract
The genetic contributions to pediatric onset ulcerative colitis (UC), characterized by severe disease and extensive colonic involvement, are largely unknown. In adult onset UC, Genome Wide Association Study (GWAS) has identified numerous loci, most of which have a modest susceptibility risk (OR 0.84–1.14), with the exception of the human leukocyte antigen (HLA) region on Chromosome 6 (OR 3.59).