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Publication Information
Affiliation
Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.; Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania, United States of America.; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.; Saint Louis University, St. Louis, Missouri, United States of America.; University of California San Diego School of Medicine, San Diego, California, United States of America.; Duke University, Durham, North Carolina, United States of America.; Duke University, Durham, North Carolina, United States of America.; Indiana University School of Medicine, Indianapolis, Indiana, United States of America.; Indiana University School of Medicine, Indianapolis, Indiana, United States of America.; Cleveland Clinic, Cleveland, Ohio, United States of America.; Indiana University School of Medicine, Indianapolis, Indiana, United States of America.; Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.; Liver Institute Northwest, Seattle, Washington, United States of America.; Cleveland Clinic, Cleveland, Ohio, United States of America.; University of Southern California, Los Angeles, California, United States of America.; University of California San Diego School of Medicine, San Diego, California, United States of America.; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.; Department of Pediatrics, Feinberg Medical School of Northwestern University, Chicago, Illinois, United States of America.; Division of Gastroenterology, Hepatology and Nutrition, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas, United States of America.; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.; Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.; Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America.
Authors
Woreta Tinsay A, Van Natta Mark L, Lazo Mariana, Krishnan Arunkumar, Neuschwander-Tetri Brent A, Loomba Rohit, Mae Diehl Anna, Abdelmalek Manal F, Chalasani Naga, Gawrieh Samer, Dasarathy Srinivasan, Vuppalanchi Raj, Siddiqui Mohammad S, Kowdley Kris V, McCullough Arthur, Terrault Norah A, Behling Cynthia, Kleiner David E, Fishbein Mark, Hertel Paula, Wilson Laura A, Mitchell Emily P, Miriel Laura A, Clark Jeanne M, Tonascia James, Sanyal Arun J
Studies
Abstract
Management of patients with NASH who are at elevated risk of progressing to complications of cirrhosis (at-risk NASH) would be enhanced by an accurate, noninvasive diagnostic test. The new FAST™ score, a combination of FibroScan® parameters liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) and aspartate aminotransferase (AST), has shown good diagnostic accuracy for at-risk NASH (area-under-the-Receiver-Operating-Characteristic [AUROC] = 0.80) in European cohorts. We aimed to validate the FAST™ score in a North American cohort and show how its diagnostic accuracy might vary by patient mix. We also compared the diagnostic performance of FAST™ to other non-invasive algorithms for the diagnosis of at-risk NASH.