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Publication Information
Authors
Jotwani Vasantha, Garimella Pranav S., Katz Ronit, Malhotra Rakesh, Bates Jeffrey, Cheung Alfred K., Chonchol Michel, Drawz Paul E., Freedman Barry I., Haley William E., Killeen Anthony A., Punzi Henry, Sarnak Mark J., Segal Mark S., Shlipak Michael G., Ix Joachim H.
Studies
Abstract
Kidney tubular atrophy on biopsy is a strong predictor of chronic kidney disease (CKD) progression, but tubular health is poorly quantified by traditional measures including estimated glomerular filtration rate (eGFR) and albuminuria. We hypothesized that urinary biomarkers of impaired tubule function would be associated with faster eGFR declines in persons with CKD.