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Number of Subjects in Study Archive: 4761
Study Design: Observational
Conditions: Gastrointestinal Diseases, Inflammatory Bowel Diseases
Division: DDN
Duration: 2003 – 2008
# Recruitment Centers: 6
Treatment: None, observational only
Available Genotype Data: Yes
Image Summary: No
Transplant Type: None
Does it have dialysis patients: No
dbGaP URL: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000130.v1.p1
Study Website: ibdgc.uchicago.edu
Data Package Version Number: 2 (Updated on: October 7, 2020)
DOI: 10.58020/t40h-p748
How to cite this dataset: Cho, Judy (2023). Inflammatory Bowel Disease Genetics (V2) [Dataset]. NIDDK Central Repository. https://doi.org/10.58020/t40h-p748
Data availability statement: Data from the Inflammatory Bowel Disease Genetics [(V2)/https://doi.org/10.58020/t40h-p748] reported here are available for request at the NIDDK Central Repository (NIDDK-CR) website, Resources for Research (R4R), https://repository.niddk.nih.gov/.
The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) and cell line repository was created in 2002 by the National Institute of Diabetes, Digestive and Kidney diseases (NIDDK) to advance knowledge on the inflammatory bowel diseases, specifically Crohn’s Disease and Ulcerative Colitis. The Consortium consists of six genetic research centers (GRC) and a data coordinating center (DCC) that prospectively recruits a combination of cases, controls, and trios to gather a large collection of samples and linked phenotype information. Phenotyping is performed using a standardized protocol, and lymphoblastoid cell lines are established for each subject. The resulting DNA samples are used to conduct genetic linkage and association studies. The IBDGC is involved with independent genetic research studies and actively works with members of the IBD and genetic communities on collaborative projects.
The primary objectives of the IBD genetics consortium include (1) recruitment of IBD cases and controls to generate a repository of biospecimen for use in research by consortium members and the scientific community and (2) conducting genetic analyses to identify genes and loci predisposing to IBD.
Phenotypes to support association studies
Participants include IBD patients, their relatives, and matched control subjects.
Specimens have been used in various analyses to identify new genes associated with bowel diseases.
Specimens and Study Datasets
| EBV Transformed Cell Lines | 79575 |
| DNA | 40793 |
| Serum | 23571 |
| Lymphocytes | 17442 |
| Cells | 9358 |
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Data Dictionary (PDF) - 49.8 KB | |
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ibd_DataReleaseDescription (PDF) - 32.0 KB | |
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ibd__dataset_integrity_check (PDF) - 111.7 KB | |
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ibd_phenotyping-forms (PDF) - 223.2 KB | |
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ibd_phenotyping-manual (PDF) - 267.3 KB | |
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ibd_roadmap (PDF) - 17.5 KB |
If you need accessible versions of documents, please email your request to NIDDK-CRsupport@niddk.nih.gov.
