Non-Study Specific CIT Data (pan-CIT)
Study Design: Clinical Trial
Conditions: Diabetes Mellitus, Diabetes Mellitus, Type 1
Duration: 2008 – 2018
# Recruitment Centers: 13
Treatment: Islet Transplantation
Available Genotype Data: No
Image Summary: No
Transplant Type: None
Does it have dialysis patients: No
The CIT consortium conducted a total of 9 studies across North America (CIT02 through CIT08) and the Nordic region (CIT01). CIT08 was a long-term follow-up study for interested participants at the North American sites. The target population is individuals with type 1 diabetes, normal kidney function, and intractable hypoglycemia. All studies treated participants with up to 3 separate infusions of islets.
Non-Study Specific CIT data are available for request
The studies investigated methods to improve the safety and efficacy of islet transplantation in treating patients with type 1 diabetes, with and without the complication of kidney failure.
Individuals diagnosed with type 1 diabetes with onset at less than 40 years of age, insulin dependence for at least 5 years at study entry, and a sum of age and insulin dependent diabetes duration of at least 28 were eligible for enrollment in the CITC studies. Specific inclusion and exclusion criteria for each of the studies are available on the individual study pages.