An official website of the United States government
The DILIN Pro study was conducted by the study investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The resources from the DILIN Pro (https://doi.org/10.58020/rs4w-6k77) study reported here were supplied by NIDDK Central Repository (NIDDK-CR) and are available for request at https://repository.niddk.nih.gov. This manuscript was not prepared under the auspices of the DILIN Pro study and does not necessarily reflect the opinions or views of the DILIN Pro study, NIDDK-CR, or NIDDK.
General Description
The Drug-Induced Liver Injury Network (DILIN) was established in 2003 as a cooperative agreement among the National Institutes of Health, 5 academic clinical centers, and a data coordinating center. A major emphasis of DILIN has been to establish a protocol for the identification and enrollment of patients with clinically significant DILI into a prospective observational study and to create a registry and specimen repository of biological samples that could be used for mechanistic studies on the etiology and prevention of DILI.
The DILIN prospective study is an ongoing multicenter observational study. Patients (2 years of age or older) were enrolled in this study if there was a strong clinical suspicion that a liver injury event was caused by a medication or an herbal agent occurring within 6 months before enrollment. Additionally, patients must meet one of the biochemical criteria for enrollment into this study.
Data from the DILIN Prospective study through the grant 3 cycle (2018) are available from the Repository.
Objectives
The goals of this study are to develop a database of recent DILI cases, identify the clinical, environmental and genetic risk factors that predict DILI, develop standardized instruments and terminology and perform careful longitudinal follow-up of DILI subjects. Biological samples collected will be used in future studies of the mechanisms and genetics of DILI.
Eligibility Criteria
- Age > 2 years at time of enrollment
- Evidence of liver injury that is known or suspected to be related to consumption of a drug or CAM product in the 6-month period prior to enrollment.
- Documented clinically important DILI, defined as any of the following:
- ALT or AST >5 x ULN or A P’ase >2 x ULN confirmed on at least 2 consecutive blood draws in patients with previously normal values
- If baseline (BL) ALT, AST or A P’ase are known to be elevated, then ALT or AST > 5 x BL or A P’ase > 2 x BL on at least 2 consecutive blood draws. “Baseline” is defined as the average of at least 2 measurements performed during the 12-month period prior to starting the DILI medication.
- Any elevation of ALT, A P’ase, or AST, associated with (a) increased total bilirubin (≥ 2.5 mg/dL), in absence of prior diagnosis of liver disease, Gilbert’s syndrome, or evidence of hemolysis or (b) coagulopathy with INR > 1.5 in absence of Coumadin therapy or known vitamin K deficiency
- Exclusion: competing cause of acute liver injury, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, other chronic biliary tract diseases, acetaminophen hepatotoxicity, liver/bone marrow transplant prior to the development of drug or CAM induced liver injury
Research Area
Liver Disease
Study Type
Observational
Study Sites
5 academic clinical centers
Study Start Date
2004-09
Study End Date
2027-07
Condition
Drug-Induced Liver Injury
Clinical Trials URL
Keywords
Alanine Aminotransferase (ALT), Drug-Induced Liver Injury (DILI), Serum Aspartate Aminotransferase (AST), Non-Prescription Medication Use, Complementary and Alternative Medications (CAM) Use, Alkaline Phosphatase (Alk Phos), Liver Elastography (FibroScans)
NIDDK Division
DDN
2,056
Participants
Target Population
Adults, Children, Dialysis Patients
Age statistics is not available for this study
Ethnicity statistics is not available for this study
Location statistics is not available for this study
Non-Public Documents (2)
Document Name | Description | Document Type | File Format |
|---|---|---|---|
Datasets (114)
Dataset Name | Description | # of Records | # of Variables | File Format(s) |
|---|---|---|---|---|
History of Injury 1 Dataset | Captures injury history; data includes drug of CAM product, rechallenged, continued, or stopped, start/stop date, WHO drug code, etc. | 3033 | sas7bdat (1.38 MB); csv (425.74 KB) | |
HIV RNA Flow Chart Dataset | Captures HIV RNA value and visit name | 396 | sas7bdat (128 KB); csv (21.15 KB) | |
Inflammation Dataset | Captures data on type on interface hepatitis, lobular inflammation, portal inflammation, confluent necrosis, granulomas, plasma cells, eosinophils, neutrophils, lymphoid aggregates, bridging necrosis, and lipogranulomas | 512 | sas7bdat (192 KB); csv (32.4 KB) | |
Screening Dataset | Captures screening data including inclusion and exclusion criteria | 2056 | sas7bdat (704 KB); csv (202.95 KB) | |
Personal History Questionnaire 1 Dataset | Captures personal history questionnaire responses; data is related to HIV/Hepatitis risk factors | 686 | sas7bdat (448 KB); csv (68.74 KB) | |
Physical Exam 1 Dataset | Captures vital signs, weight, and height data from physical exam | 3720 | sas7bdat (768 KB); csv (257.39 KB) | |
Symptoms Dataset | Captures data on symptoms such as skin rash, nausea, poor appetite, pain over the liver area, tired or fatigued, itching of the skin, muscle/joint aches and pain, fever and chills, weakness of the arms or legs, depressed/sadness, and how the subject feels overall | 2453 | sas7bdat (576 KB); csv (189.07 KB) | |
Protocol Exemption Dataset | Captures reasons for patient exemption from protocol | 1983 | sas7bdat (704 KB); csv (220.83 KB) | |
Interval HIV Status C Dataset | Captures HIV infection since last visit, HIV progression to AIDS, date of HIV diagnosis, and date of AIDS diagnosis | 2082 | sas7bdat (448 KB); csv (144.51 KB) | |
RAND 36 Health Survey 2 Dataset | Captures data on health status and quality of life from patient-reported SF-36 Health Survey | 2355 | sas7bdat (512 KB); csv (144.1 KB) | |
Chronic Inclusion/Exclusion Dataset | Captures data on inclusion/exclusion criteria (liver transplant by 6 month visit, chronic HBV or HCV prior to implicated med start, persistently elevated liver function test, etc.) | 1637 | sas7bdat (384 KB); csv (100.71 KB) | |
HIV/Hepatitis Risk Factors Dataset | Captures data on exposures including blood transfusions, relationships, direct contact with patient body fluids/secretions, injection drug use, substance use, needle stick injury travel outside USA in 6 months before sick with liver injury, etc. | 223 | sas7bdat (192 KB); csv (25.83 KB) | |
Laboratory Results Dataset | Captures laboratory test results (ALT, alkaline phosphatase, bilirubin, AST, albumin, INR, etc.) | 475 | sas7bdat (256 KB); csv (50.63 KB) | |
General Medication Compliance Dataset | Captures general medication compliance information; data includes taking medications more or less frequently than prescribed and how closely the subject follows the medication schedule | 1369 | sas7bdat (256 KB); csv (67.64 KB) | |
Standard Lab Flow Chart Dataset | Captures laboratory test results (serum direct bilirubin, BUN, INR, neutrophils, serum creatinine, blood platelets, cholesterol, serum albumin, potassium, lymphocytes, etc.) | 20508 | sas7bdat (5.63 MB); csv (2.1 MB) | |
Smoking History Dataset | Captures smoking history data, including oldest age, cigarettes per day, youngest age, cigars per day, and pipes per week | 749 | sas7bdat (192 KB); csv (41.91 KB) | |
Fibrosis Dataset | Captures data on fibrosis stage and perisinusoidal degree | 512 | sas7bdat (128 KB); csv (24.74 KB) | |
Biopsy 1 Dataset | Captures data on stains available, bridging necrosis, total portal areas, biopsy type, inflammation, specimen type, liver length, stage, neutrophils, interface hepatitis, plasma cells, acute cholangitis, etc. | 254 | sas7bdat (192 KB); csv (29.07 KB) | |
Research Samples Dataset | Captures data on whether blood sample was provided, subject received a liver biopsy, urine sample provided, and dates of blood and urine collection | 4042 | sas7bdat (704 KB); csv (237.32 KB) | |
Early Withdrawal and Study Completion Dataset | Captures data on early withdrawal and study completion, including primary reason, death, sepsis, renal failure, etc., date of event, and whether the participant completed the study | 1938 | sas7bdat (576 KB); csv (172.62 KB) | |
Anti-HEV Dataset | Captures anti-HEV testing visit date | 1931 | sas7bdat (256 KB); csv (98.1 KB) | |
Past Allergy History Dataset | Captures allergy history data, including agents, standardized medication names, WHO drug codes, and past reactions | 1899 | sas7bdat (960 KB); csv (187.09 KB) | |
Emergency Room, Hospital, and Medical Appointment History Dataset | Captures ER, hospital, and medical appointment history; data includes inform visit name/number, admitted to emergency room since last visit, seen by other physician since last visit, and admitted to hospital since last visit | 2168 | sas7bdat (384 KB); csv (104.06 KB) | |
Personal History Questionnaire 8 Dataset | Captures personal history questionnaire responses; data includes types of meat | 257 | sas7bdat (192 KB); csv (19.24 KB) | |
HCV RNA Flow Chart Dataset | Captures HCV RNA value, units, and results | 274 | sas7bdat (128 KB); csv (16.64 KB) | |
Concomitant CAM Products Dataset | Captures concomitant CAM products information, such as brand name, common name, continuing status, WHO drug code, start/stop date, and standardized medication name | 3748 | sas7bdat (1.5 MB); csv (436.27 KB) | |
Standard Labs 2 Dataset | Captures laboratory test results (serum direct bilirubin, BUN, INR, neutrophils, serum creatinine, blood platelets, cholesterol, serum albumin, potassium, lymphocytes, etc.) | 3860 | sas7bdat (1.75 MB); csv (620.06 KB) | |
Past Medical History - Liver Specific Dataset | Captures liver-specific past medical history; data includes type of liver disease and active condition | 413 | sas7bdat (128 KB); csv (19.12 KB) | |
Questionnaires 1 Dataset | Captures data on alcohol use and smoking habits over past 5 years | 1978 | sas7bdat (384 KB); csv (104.53 KB) | |
Interval HIV Status 1 Dataset | Captures HIV status data including any infections, pertinent serologies/serum level tests performed, and urine toxicology results | 60 | sas7bdat (128 KB); csv (9.21 KB) | |
Signs and Symptoms 2 Dataset | Captures data on symptoms and signs of liver injury, including first onset date | 669 | sas7bdat (192 KB); csv (43.42 KB) | |
Past Medical History 1 Dataset | Captures past medical history; data includes past and active conditions | 7812 | sas7bdat (1 MB); csv (360.14 KB) | |
CAMMED 2 Dataset | Captures CAM ingredient number and list of ingredients | 4939 | sas7bdat (1.13 MB); csv (406.15 KB) | |
Travel History Dataset | Captures data on type of area, country, and duration | 20 | sas7bdat (128 KB); csv (1.57 KB) | |
Acute Blood Samples and Labs Dataset | Captures data on whether acute blood samples or labs were drawn | 129 | sas7bdat (128 KB); csv (5.67 KB) | |
Judgement Dataset | Captures data on causality process, implicated drug assessment, reviewer, DILIN's severity score, symptoms, implicated drug WHO name and code, alternative diagnosis, death due to DILI, re-assessment reason, transplant listing, patient vital status, etc. | 11825 | sas7bdat (59.38 MB); csv (2.72 MB) | |
Biopsy Demographics Dataset | Captures biopsy demographics data, including specimen type, total portal areas, liver weight, and stains available | 512 | sas7bdat (320 KB); csv (45.5 KB) | |
Visit Status Dataset | Captures data on whether the patient completed the visit | 6342 | sas7bdat (960 KB); csv (326 KB) | |
Pharmacy 1 Dataset | Captures data on source of prescription medications, including mail-order pharmacy, local independently owned pharmacy, national pharmacy chain, samples from doctors' offices, hospital or clinic-based pharmacy, and how many different pharmacies during the last 12 months | 500 | sas7bdat (192 KB); csv (34 KB) | |
Interval General Smoking History Dataset | Captures smoking data including regular tobacco inhalation and smoking preference (pipe, cigar, cigarette) | 221 | sas7bdat (128 KB); csv (11.44 KB) | |
Past Surgical History Dataset | Captures dates of any past surgeries | 2928 | sas7bdat (448 KB); csv (144.18 KB) | |
Skinner Alcohol Consumption Dataset | Captures data related to alcohol consumption, including peer group, legal/jail, work, frequency, family, age range, residence, maximum, drug abuse, and beer, wine, and liquor consumption | 1784 | sas7bdat (640 KB); csv (198.95 KB) | |
Imaging Studies Dataset | Captures imaging studies data, including biliary dilation, ascites, splenomegaly, spleen diameter, hepatomegaly, gallstones, liver tumor, normal study, etc. | 5413 | sas7bdat (1.25 MB); csv (457.16 KB) | |
Interval History/Questionnaires Dataset | Captures any changes in medical history, liver-specific medical history, surgical history, or allergy history since last visit | 2059 | sas7bdat (384 KB); csv (102.68 KB) | |
Enrollment Dataset | Captures enrollment data including study (prospective or retrospective), date of visit, and subject IDs | 2056 | sas7bdat (192 KB); csv (55.88 KB) | |
Personal History Questionnaire 2 Dataset | Captures personal history questionnaire responses; data includes type of animal | 162 | sas7bdat (128 KB); csv (7 KB) | |
Biopsy 2 Dataset | Captures data on stain used, hepatocyte rosettes, hemorrhage, CK 7 evaluation, lobular disarray, mallory bodies, ballooning degeneration, nodular transformation, etc. | 254 | sas7bdat (192 KB); csv (25.77 KB) | |
Physical Exam 2 Dataset | Captures any abnormalities and/or conditions data from physical exam | 3670 | sas7bdat (896 KB); csv (254.66 KB) | |
Miscellaneous Changes Dataset | Captures data on miscellaneous biopsy changes that do not require stains, such as hepatocyte ground glass change, mallory bodies, lipen-laden stellate cells, etc. | 512 | sas7bdat (192 KB); csv (28.96 KB) | |
Special Stain Evaluation Dataset | Captures special stain evaluation (only performed if particular stain is available) data, such as iron, copper, and PAS/diastase stains | 512 | sas7bdat (128 KB); csv (28.02 KB) | |
Hepatitis Status Dataset | Captures hepatitis status data, including type of infection and historic laboratory test results | 2036 | sas7bdat (448 KB); csv (123.36 KB) | |
RAND 36 Health Survey 3 Dataset | Captures data on health status and quality of life from patient-reported SF-36 Health Survey | 2351 | sas7bdat (576 KB); csv (162.31 KB) | |
Questionnaires 2 Dataset | Captures data on alcohol use and smoking habits since last visit | 1795 | sas7bdat (320 KB); csv (91.82 KB) | |
Hospitalization Visit Dataset | Captures hospitalization data including any abdominal imaging studies performed, liver function tests performed, total days in hospital, admitted date, and discharge date | 840 | sas7bdat (256 KB); csv (55.01 KB) | |
Interval HIV Status A Dataset | Captures positive substances from urine toxicology among patients with HIV | 13 | sas7bdat (128 KB); csv (751 B) | |
Interval Hepatitis Status Dataset | Captures data on hepatitis C or hepatitis B diagnoses since last visit, HBV DNA results since last visit, use of non-implicated hepatitis C medication since last visit, any Anti-HBe, HCV RNA, or HBeAG results since last visit | 1653 | sas7bdat (384 KB); csv (92.1 KB) | |
Diagnostic Labs 3 Dataset | Captures laboratory test results (beta, gamma, serum protein electrophoresis, additional ANA or ASMA, albumin, alpha-2, alpha-1) | 2007 | sas7bdat (448 KB); csv (140.14 KB) | |
Signs and Symptoms Dataset | Captures signs and symptoms and their date of onset | 8402 | sas7bdat (1.19 MB); csv (440.09 KB) | |
Annual Concomitant Medications Dataset | Captures annual concomitant medication information, including standardized medication name, WHO ATC code and text, WHO drug code, continuing, and start and stop date | 2243 | sas7bdat (1 MB); csv (305.47 KB) | |
Signs and Symptoms 1 Dataset | Captures data on symptoms and signs of liver injury, including first onset date | 1588 | sas7bdat (448 KB); csv (102.46 KB) | |
Interval Hepatitis Status 2 Dataset | Captures data on non-implicated hepatitis medications since last visit | 417 | sas7bdat (128 KB); csv (18.68 KB) | |
Interval HIV Status 2 Dataset | Captures HIV status serology unit, type, value, results, and date | 424 | sas7bdat (256 KB); csv (30.34 KB) | |
CD4 Flow Chart Dataset | Captures data on CD4+ laboratory test results | 428 | sas7bdat (128 KB); csv (22.62 KB) | |
History of Injury 2 Dataset | Captures liver injury history; data includes liver transplant, hospitalization, disruption to daily living, seen by gastroenterologist/hepatologist for DILI event, thrombocytopenia, serum sickness, hemolytic anemia, etc. | 2036 | sas7bdat (768 KB); csv (241.49 KB) | |
CAMMED 3 Dataset | Captures medication frequency, HDS #, dose, route, unit, continuing status, indication, and start/stop date | 820 | sas7bdat (576 KB); csv (78.71 KB) | |
Drug Specific Medication Compliance Dataset | Captures drug compliance data including drug name and whether the prescribed medication schedule is followed | 2345 | sas7bdat (640 KB); csv (159.82 KB) | |
Implicated DILI Medication Dataset | Captured implicated DILI medication information; data includes frequency, route, indication, medication, unit, dose, start/stop date, WHO drug code, WHO ATC code, and WHO ATC text | 3506 | sas7bdat (2.95 MB); csv (649.46 KB) | |
Abdominal Imaging Studies Dataset | Captures whether abdominal imaging studies were performed and the inform visit name | 2110 | sas7bdat (320 KB); csv (92.74 KB) | |
HIV Status Dataset | Captures whether the patient has a known HIV infection | 2038 | sas7bdat (384 KB); csv (101.3 KB) | |
Source of Prescription Medications Dataset | Captures data on source of prescription medications, including mail-order pharmacy, local independently owned pharmacy, national pharmacy chain, samples from doctors' offices, hospital or clinic-based pharmacy, and how many different pharmacies during the last 12 months | 1316 | sas7bdat (320 KB); csv (87.65 KB) | |
Blood Draw Details Dataset | Captures information about patient's location during blood draw, including visit, date of admission, date of discharge, and date of collection | 445 | sas7bdat (192 KB); csv (29.45 KB) | |
Major Medical Outcomes Dataset | Captures major medical outcomes; data includes liver transplant and death | 2146 | sas7bdat (384 KB); csv (111.73 KB) | |
Concomitant History Dataset | Captures concomitant history, including any CAM products and medications used during the study | 2018 | sas7bdat (320 KB); csv (86.4 KB) | |
Medical Appointment History Dataset | Captures medical appointment history data, including any liver function tests performed, abdominal imaging studies performed, and whether the emergency room visit was DILI-related | 8497 | sas7bdat (1.25 MB); csv (460.6 KB) | |
Emergency Room Visit Dataset | Captures emergency room visit information including whether the visit was DILI-related, total days in hospital, whether abdominal imaging studies were performed, whether liver function tests were performed, date of admittance, and date of discharge | 604 | sas7bdat (192 KB); csv (40.87 KB) | |
Personal History Questionnaire 3 Dataset | Captures personal history questionnaire responses; data includes type of area | 609 | sas7bdat (192 KB); csv (25.94 KB) | |
Pattern Dataset | Captures data on pattern of injury (vascular, granulomatous, acute cholestatic, chronic cholestatic, mixed or unclassified, absolutely normal, hepatocellular alteration, etc.) | 512 | sas7bdat (128 KB); csv (22.28 KB) | |
Standard Labs (Within 4 Weeks Prior to Onset) Dataset | Captures laboratory test results within 4 weeks prior to onset (serum direct bilirubin, BUN, INR, neutrophils, serum creatinine, blood platelets, cholesterol, serum albumin, potassium, lymphocytes, etc.) | 1217 | sas7bdat (704 KB); csv (230.63 KB) | |
Fibroscan Dataset | Captures data on current waist, hip, and chest circumference, weight, highest fibro scan velocity, sex, shortening fraction, CAP measurements, last food/drink, pregnancy test results, etc. | 277 | sas7bdat (320 KB); csv (77.22 KB) | |
Interval HIV Status B Dataset | Captures positive test result substance among patients with HIV | 8 | sas7bdat (128 KB); csv (498 B) | |
HBeAG Flow Chart Dataset | Captures HBeAg laboratory result | 66 | sas7bdat (128 KB); csv (3.42 KB) | |
Diagnostic Labs 2 Dataset | Captures laboratory test results (serum ferritin, serum IgA, anti CMV IgM, serum iron, serum alpha-1 antitrypsin, serum transferrin, etc.) | 2026 | sas7bdat (1 MB); csv (341.35 KB) | |
Concomitant Medications Dataset | Captures concomitant medications data, such as brand name, common name, continuing status, WHO drug code, start/stop date, and standardized medication name | 27462 | sas7bdat (11.25 MB); csv (3.56 MB) | |
CAMMED 4 Dataset | Captures data including prescribed medication and reason | 3 | sas7bdat (128 KB); csv (381 B) | |
McKesson Dataset | Captures McKesson visit number | 85372 | sas7bdat (6 MB); csv (4.31 MB) | |
DILIN HCV Dataset | Captures data on HCV comments, genotype, test type, results, etc. | 998 | sas7bdat (384 KB); csv (127.94 KB) | |
Interval HIV Status 3 Dataset | Captures HIV status data including any infections, pertinent serologies/serum level tests performed, and urine toxicology results | 53 | sas7bdat (128 KB); csv (7.79 KB) | |
Urinalysis Dataset | Captures urinalysis results, including RBC value, bacteria value, crystals, bilirubin, protein/albumin, and other values | 1322 | sas7bdat (896 KB); csv (176.93 KB) | |
RUCAM Score Dataset | Captures data on reviewer, calculated RUCAM score, name of implicated drug/CAM, and implicated drug WHO name and code | 45867 | sas7bdat (16.56 MB); csv (4.14 MB) | |
General Smoking History Dataset | Captures smoking data including duration of smoking in years, regular tobacco inhalation and smoking preference (cigarette, pipe, cigar) | 515 | sas7bdat (192 KB); csv (27.49 KB) | |
Annual Concomitant History Dataset | Captures annual concomitant history data, including visit name and any CAM products or medications used within 4 weeks of annual visit | 402 | sas7bdat (128 KB); csv (18.82 KB) | |
Anti-HBe Flow Chart Dataset | Captures anti-HBe laboratory result | 54 | sas7bdat (128 KB); csv (2.81 KB) | |
HIV Medication Log Dataset | Captures HIV medication log data, including continuing status, route, medication, dose, unit, frequency, start/stop date, WHO drug code, and standardized medication name | 179 | sas7bdat (192 KB); csv (20.23 KB) | |
Liver Biopsy for Hepatitis Patients Dataset | Captures liver biopsy data for hepatitis patients, including length of specimen, adequacy of biopsy, inflammation, fibrosis stage, steatosis, iron storage, etc. | 8 | sas7bdat (128 KB); csv (714 B) | |
RAND 36 Health Survey 1 Dataset | Captures data on health status and quality of life from patient-reported SF-36 Health Survey | 2364 | sas7bdat (576 KB); csv (153.93 KB) | |
Anti-HDV (Total) Flow Chart Dataset | Captures anti-HDV laboratory result | 11 | sas7bdat (128 KB); csv (647 B) | |
Serology Flow Chart Dataset | Captures serology data including value, type of test, results, and threshold value | 862 | sas7bdat (256 KB); csv (54.07 KB) | |
Biopsy Collection Dataset | Captures data on biopsy collection, such as cryovial/cryomold, slides to, DILI biopsy type, etc. | 837 | sas7bdat (320 KB); csv (78.44 KB) | |
Cholestasis Dataset | Captures cholestasis data on degree and presence or absence of hepatocellular, canalicular, cholangiolar, and ductal; also collects data on ductular reaction, duct injury, duct paucity, and acute cholangitis | 512 | sas7bdat (192 KB); csv (32.92 KB) | |
Vascular Dataset | Captures data on veno-occlusive changes in central veins, central vein endophlebitis, portal venopathy, hemorrhage, sinusoidal dilation, and nodular transformation | 512 | sas7bdat (192 KB); csv (28.9 KB) | |
Steatosis Dataset | Captures steatosis data including character, location, and degree | 512 | sas7bdat (128 KB); csv (25.75 KB) | |
Personal History Questionnaire 12 Dataset | Captures personal history questionnaire responses; data includes direct contact with patient fluids/secretions and history of needle stick exposure or injury at work | 69 | sas7bdat (128 KB); csv (3.14 KB) | |
RUCDR CT Dataset | Captures shipment status, DNA yield (ug), total tub, volume, cryopreserved date, blood received date, and sample drawn date | 5241 | sas7bdat (3.19 MB); csv (334.13 KB) | |
Standard Labs 1 Dataset | Captures laboratory test results (serum direct bilirubin, BUN, INR, neutrophils, serum creatinine, blood platelets, cholesterol, serum albumin, potassium, lymphocytes, etc.) | 3861 | sas7bdat (1.5 MB); csv (512.83 KB) | |
Hepatitis Medications Log Dataset | Captures data on medications including continuing status, start/stop date, standardized medication name, and WHO drug code | 42 | sas7bdat (128 KB); csv (4.38 KB) | |
Annual Concomitant CAM Products Dataset | Captures annual concomitant CAM product use information, including standardized medication name, WHO drug code, common name, and start and stop date | 345 | sas7bdat (256 KB); csv (40.87 KB) | |
Diagnostic Labs 1 Dataset | Captures laboratory test results (Anti-HIV, ANA, ASNA, anti-HDV, serum ceruloplasmin, HBeAg, etc.) | 2027 | sas7bdat (1.56 MB); csv (522.37 KB) | |
CAMMED 1 Dataset | Captures product name, product line, HDS #, HDS ingredients available, manufacturer's name, standardized medication name, and WHO drug code | 770 | sas7bdat (448 KB); csv (120.5 KB) | |
Hepatitis Injury Dataset | Captures data on ballooning degeneration, apoptosis, coagulative necrosis location and degree, and lobular disarray | 512 | sas7bdat (128 KB); csv (26.29 KB) | |
Signs and Symptoms 3 Dataset | Captures data on symptoms and signs of liver injury, including first onset date | 552 | sas7bdat (192 KB); csv (33.43 KB) | |
Liver Test Flow Chart Dataset | Captures laboratory test results (AST, serum total bilirubin, AST, INR ratio, etc.) | 33571 | sas7bdat (9.31 MB); csv (3.71 MB) | |
Demographics Dataset | Captures demographic data including sex, race, and age category | 2056 | sas7bdat (384 KB); csv (116.17 KB) | |
Past Medical History 2 Dataset | Captures past medical history; data includes past surgeries, allergies, imaging studies, liver conditions, and any other medical conditions/diseases | 2039 | sas7bdat (448 KB); csv (114.98 KB) | |
HBV DNA Flow Chart Dataset | Captures HBV DNA value, units, and results | 85 | sas7bdat (128 KB); csv (5.17 KB) |
Specimens (138,041)
Specimen | Count |
|---|---|
| Cells | 122 |
| DNA | 6155 |
| EBV Transformed Cell Lines | 985 |
| Externally Produced Serum | 686 |
| Liver Tissue | 10 |
| Lymphocytes | 3737 |
| Plasma | 53809 |
| RNA | 825 |
| Serum | 34880 |
| Urine | 36832 |