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Citation
Xie, Changchun (2024). Adolescent Bariatrics: Assessing Health Benefits & Risks (Teen-LABS) (Version 4) [Dataset] NIDDK Central Repository. https://doi.org/10.58020/f87q-jn46
Data Availability Statement
Data from the Adolescent Bariatrics: Assessing Health Benefits & Risks (Teen-LABS) [(Version 4) https://doi.org/10.58020/f87q-jn46] reported here are available for request at the NIDDK Central Repository (NIDDK-CR) website, Resources for Research (R4R), https://repository.niddk.nih.gov/.
Acknowledgment Statement
The Teen-LABS study was conducted by the study investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The resources from the Teen-LABS (https://doi.org/10.58020/f87q-jn46) study reported here were supplied by NIDDK Central Repository (NIDDK-CR) and are available for request at https://repository.niddk.nih.gov. This manuscript was not prepared under the auspices of the Teen-LABS study and does not necessarily reflect the opinions or views of the Teen-LABS study, NIDDK-CR, or NIDDK.
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General Description

Teen-LABS conducted coordinated clinical, epidemiological, and behavioral research focused on adolescent bariatric surgery. The study developed common clinical protocols and a bariatric surgery database for the purpose of collecting information from participating clinical centers that performed bariatric surgery on teenagers. Outside of investigating surgical outcomes, Teen-LABS sought to better understand the etiology, pathophysiology, and behavioral aspects of severe obesity in youth as well as how severe obesity impacts humans over time. Participants were recruited from six clinical centers and underwent bariatric surgery. Pre- and post-surgery data and biospecimens were obtained at pre-determined points.

Objectives

The objective of the Teen-LABS study was to use standardized techniques to assess the short and longer-term safety and efficacy of bariatric surgery in adolescents compared to adults.

Outcome Measure

The primary outcome measures for Teen-LABS included:

  • Percent change in body mass index from baseline
  • Change in number of participants achieving remission from baseline type 2 diabetes (T2D)
  • Change in number of participants achieving remission from baseline hypertension
The secondary outcome measures for Teen-LABS included:
  • Number of participants with hypoferritinemia
  • Number of participants with hypovitaminosis B12
  • Occurrence of abdominal re-operations
Eligibility Criteria

Inclusion criteria:

  • Individuals < 19 years of age
  • Approved to undergo bariatric surgery by a Teen-LABS certified surgeon at one of the Teen-LABS clinical sites
  • Primary caregivers of adolescent participants (for their weight, height, and demographic variables only)
  • Informed consent/assent obtained

Exclusion criteria:

  • Individuals 19 years or older
  • Informed consent/assent not obtained
  • Unable to communicate with local study staff
Outcome

The study found that younger adolescents with severe obesity should not be denied surgical intervention based on age alone. Providers should consider adolescents of all ages as candidates for surgical intervention for obesity when surgery is clinically indicated.

Research Area

Diabetes, Obesity, Multidisciplinary Research

Study Type

Observational

Study Sites

6

Study Start Date

2007-03

Study End Date

2023-08

Condition

Obesity Disorder, Type 2 Diabetes Mellitus, Hypertensive Disorder

Keywords

Hypoferritinemia, Diabetes, Abdominal Re-Operations, Observational Study, Hypovitaminosis B12, Bariatric Surgery

NIDDK Division

DDN

242
Participants

Target Population
Children
Location statistics is not available for this study

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Non-Public Documents (6)
Non-Public Documents Table
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Datasets (289)
Datasets Table
Dataset Name
Description
# of Records
# of Variables
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Specimens (41,714)
Specimens Table
Specimen
Count
DNA247
Plasma11314
Serum13100
Urine17053