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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2016
Affiliation
Department of Internal Medicine and Department of Health Management and Policy, University of Michigan, Ann Arbor, MI, USA.
Authors
Altman DG, Dahabreh IJ, Hayward RA, Kent DM, Nelson J, Rothwell PM
Citation
Kent DM, Nelson J, Dahabreh IJ, Rothwell PM, Altman DG, Hayward RA. Risk and treatment effect heterogeneity: re-analysis of individual participant data from 32 large clinical trials. Int J Epidemiol 2016 Dec 1;45(6):2075-2088.

Abstract

Risk of the outcome is a mathematical determinant of the absolute treatment benefit of an intervention, yet this can vary substantially within a trial population, complicating the interpretation of trial results.