PubMed ID:
26010309
Public Release Type:
Journal
Publication Year: 2015
Affiliation: 1] Pediatric Epidemiology Center, University of South Florida, Tampa, Florida, USA [2] Department of Clinical Sciences, Lund University, Malmo, Sweden.
DOI:
https://doi.org/10.1038/ajg.2015.150
Authors:
Agardh D,
Akolkar B,
Bugawan TL,
Chen WM,
Erlich H,
Hadley D,
Hagopian W,
Krischer JP,
Liu E,
Onengut-Gumuscu S,
Rewers M,
Rich SS,
She JX,
Simell O,
TEDDY Study Group,
Ziegler AG
Studies:
The Environmental Determinants of Diabetes in the Young
Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen (HLA) factors other than DR3-DQ2 for their contribution to developing tTGAs.