PubMed ID:
25660258
Public Release Type:
Journal
Publication Year: 2015
Affiliation: Department of Pediatrics, Morsani College of Medicine, University of South Florida, 3650 Spectrum Boulevard, Suite 100, Tampa, FL, 33612, USA, jeffrey.krischer@epi.usf.edu.
DOI:
https://doi.org/10.1007/s00125-015-3514-y
Authors:
Ilonen J,
Toppari J,
Akolkar B,
Bonifacio E,
Hagopian WA,
Krischer JP,
Lernmark Å,
Lynch KF,
Rewers MJ,
Schatz DA,
She JX,
Simell OG,
TEDDY Study Group,
Ziegler AG
Studies:
The Environmental Determinants of Diabetes in the Young
Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes. These autoantibodies are detectable for a variable period of time before diabetes onset. Thus, the occurrence of islet autoantibodies is associated with the beginning of the disease process. The age at, and order in, which autoantibodies appear may be associated with different genetic backgrounds or environmental exposures, or both.