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Publication Information
Affiliation
Department of Pediatrics, Morsani College of Medicine, University of South Florida, 3650 Spectrum Boulevard, Suite 100, Tampa, FL, 33612, USA, jeffrey.krischer@epi.usf.edu.
Authors
Akolkar B, Bonifacio E, Hagopian WA, Ilonen J, Krischer JP, Lernmark Å, Lynch KF, Rewers MJ, Schatz DA, She JX, Simell OG, TEDDY Study Group, Toppari J, Ziegler AG
Studies
Citation
Krischer JP, Lynch KF, Schatz DA, Ilonen J, Lernmark Å, Hagopian WA, Rewers MJ, She JX, Simell OG, Toppari J, Ziegler AG, Akolkar B, Bonifacio E, TEDDY Study Group. The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study. Diabetologia 2015 May;58(5):980-7. Epub 2015 Feb 10.Abstract
Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes. These autoantibodies are detectable for a variable period of time before diabetes onset. Thus, the occurrence of islet autoantibodies is associated with the beginning of the disease process. The age at, and order in, which autoantibodies appear may be associated with different genetic backgrounds or environmental exposures, or both.