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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2014
Affiliation
From the Digestive Health Institute, Children's Hospital Colorado (E.L.), and the Barbara Davis Center (E.L., M.J.R., G.S.E.), University of Colorado Denver, Aurora; the Pediatrics Epidemiology Center, University of South Florida, Tampa (H.-S.L.); the Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmo, Sweden (C.A.A., D.A.); Pacific Northwest Diabetes Research Institute, Seattle (W.A.H.); Dr. von Hauner Children's Hospital, Ludwig Maximilian University, Munich (S.K.), the Center for Regenerative Therapies Dresden, Technische Universitaet Dresden, Dresden (E.B.), and Forschergruppe Diabetes, Helmholz Zentrum München, Neuherberg (E.B.) - all in Germany; the School of Clinical Sciences, University of Bristol, Bristol, United Kingdom (P.J.B.); and the Department of Pediatrics, University of Turku, Turku University Hospital, Turku, Finland (V.S.).
Authors
Abbondondolo M, Åberg S, Agardh D, Åkerlund M, Akolkar B, Anderson SW, Aronsson CA, Ask M, Austin-Gonzalez S, Ayres S, Bautista K, Baxter J, Becker D, Bedoy R, Beyerlein A, Bingley P, Bingley PJ, Boldison J, Bonifacio E, Bourcier K, Bremer J, Briese T, Broadhurst J, Brown R, Burkhardt B, Butterly J, Butterworth M, Carlsson UM, Carreno G, Caygill C, Chandler K, Chen WM, Cilio C, Crouch CC, Curnock R, Cuthbertson D, Daftary A, Davis J, Dunson K, Easton P, Eberhard C, Eisenbarth GS, Ekstrand C, Ericson-Hallström E, Eriksson EA, Erlich H, Erlund I, Farber E, Fear AL, Fiehn O, Fiske S, Foghis G, Foterek K, Franciscus M, Fransson L, Gallo D, Garcia D, Gardiner M, Gard T, Gaur VP, Geoghan I, Gerardsson J, Gesualdo P, Goode J, Gowda V, Hadley D, Hagopian WA, Håkansson R, Haller M, Hansen M, Hansson G, Heaney D, Hervey R, Higgins H, Hoffman M, Hopkins D, Hummel M, Hummel S, Hyberg S, Hyöty H, Ilonen J, Järvirova MS, Jiang N, Johansen F, Johnson SB, Jonasdottir B, Jonsson L, Kähönen M, Karban R, Karlsson EL, Kersting M, Ke S, Killian M, Kindschi R, Kind T, Klein MB, Knip M, Knopff A, Koivu A, Koletzko S, Koreasalo M, Krischer JP, Kurppa K, Larsson H, Lee HS, Lehtonen M, Leiviskä J, Lernmark Å, Lernmark B, Little RR, Liu E, Liu H, Liu S, Liu X, Long A, Lönnrot M, Lynch K, Mack SJ, Malloy J, Månsson-Martinez M, Mäntymäki E, Marcovina SM, Markan M, Massadakis T, McCarthy C, McIndoe R, McLeod W, Melin J, Mestan Z, Meyer A, Miao D, Mulenga D, Multasuo K, Mykkänen J, Nechtman J, Niininen T, Norris J, Nyblom M, Oberste S, Onengut-Gumuscu S, Palazoglu M, Payne M, Pearson J, Peplow C, Petrosino JF, Pickin RR, Rahmati K, Ramelius A, Rautanen J, Reed C, Rewers M, Rewers MJ, Rich SS, Ridewood S, Riikonen A, Rokni S, Romo M, Roth R, Salminen I, Samper-Imaz A, Schatz D, Scott E, Shaffer C, Shankar M, Sharma A, Sheehan E, She JX, Sibthorpe S, Silvis K, Simell A, Simell B, Simell OG, Simell S, Simell T, Simell V, Sjöberg B, Sjöberg M, Skidmore J, Smith L, Smith MD, Smith S, Stabbert J, Steck A, Steed L, Stenius A, Stock J, Strauss E, Sundvall J, Swartling U, Tamura R, TEDDY Study Group, Tennill AL, Thomas J, Toppari J, Törn C, Triplett E, Trulsson E, Uusitalo U, Varjonen E, Vehik K, Veijola R, Virtanen SM, Wallin A, Warncke K, Washington E, Waugh K, Wikoff B, Williams A, Williams J, Williams N, Willis J, Wimar Å, Winkler C, Wohlgemuth G, Wong J, Wyatt R, Yang J, Yan X, Yu L, Zhao Y, Ziegler AG
Studies
Citation
Liu E, Lee HS, Aronsson CA, Hagopian WA, Koletzko S, Rewers MJ, Eisenbarth GS, Bingley PJ, Bonifacio E, Simell V, Agardh D, TEDDY Study Group. Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med 2014 Jul 3;371(1):42-9.

Abstract

The presence of HLA haplotype DR3-DQ2 or DR4-DQ8 is associated with an increased risk of celiac disease. In addition, nearly all children with celiac disease have serum antibodies against tissue transglutaminase (tTG).