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Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2014
Affiliation
Department of Pediatrics, Pediatrics Epidemiology Center, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Authors
Abbondondolo M, Åberg S, Agardh D, Åkerlund M, Akolkar B, Anderson SW, Andrén-Aronsson C, Ask M, Austin-Gonzalez S, Ayres S, Barriga K, Bautista K, Baxter J, Becker D, Bedoy R, Beyerlein A, Bingley P, Boldison J, Bonifacio E, Bourcier K, Bremer J, Briese T, Broadhurst J, Brown R, Burkhardt B, Butterly J, Butterworth M, Carlsson UM, Carreno G, Caygill C, Chandler K, Chen WM, Cilio C, Crouch CC, Curnock R, Cuthbertson D, Daftary A, Davis B, Davis J, Dresden TU, Dunson K, Easton P, Eberhard C, Eisenbarth G, Ericson-Hallström E, Eriksson EA, Erlich H, Erlund I, Farber E, Fear AL, Fiehn O, Fiske S, Foghis G, Foterek K, Franciscus M, Frank N, Fransson L, Gallo D, Gardiner M, Gard T, Gaur VP, Geoghan I, Gerardsson J, Gesualdo P, Goode J, Gowda V, Hadley D, Hagopian WA, Håkansson R, Haller M, Hansen M, Hansson G, Heaney D, Hervey R, Higgins H, Hoffman M, Hopkins D, Hummel M, Hummel S, Hyberg S, Hyöty H, Ide L, Ilonen J, Järvirova MS, Jiang N, Johansen F, Johnson SB, Jonasdottir B, Jonsson L, Kähönen M, Karban R, Karlsson EL, Kersting M, Ke S, Killian M, Kindschi R, Kind T, Klein MB, Knip M, Knopff A, Koivu A, Koletzko S, Koreasalo M, Krischer JP, Kurppa K, Larsson H, Larsson HE, Lee HS, Lehtonen M, Leiviskä J, Lernmark Å, Lernmark B, Little RR, Liu E, Liu H, Liu S, Liu X, Long A, Lönnrot M, Lynch K, Lynch KF, Mack SJ, Malloy J, Månsson-Martinez M, Mäntymäki E, Marcovina SM, Markan M, Massadakis T, McCarthy C, McIndoe R, McLeod W, Melin J, Mestan Z, Meyer A, Miao D, Mulenga D, Multasuo K, Mykkänen J, Näntö-Salonen K, Nechtman J, Niininen T, Norris J, Nyblom M, Oberste S, Onengut-Gumuscu S, Palazoglu M, Payne M, Pearson J, Peplow C, Petrosino JF, Pickin RR, Rahmati K, Ramelius A, Rautanen J, Reed C, Rewers M, Rich SS, Ridewood S, Riikonen A, Rokni S, Romo M, Rosenquist A, Roth R, Salminen I, Samper-Imaz A, Schatz D, Schenkel J, Scott E, Shankar M, Sharma A, Sheehan E, She JX, Sibthorpe S, Silvis K, Simell A, Simell B, Simell OG, Simell S, Simell T, Simell V, Sjöberg B, Sjöberg M, Skidmore J, Smith L, Smith MD, Smith S, Stabbert J, Steck A, Steed L, Stenius A, Stock J, Strauss E, Sundvall J, Swartling U, Tamura R, TEDDY Study Group, Tennill AL, Thomas J, Toppari J, Törn C, Triplett E, Trulsson E, Uusitalo U, Uusitalo UM, Varjonen E, Vehik K, Veijola R, Virtanen SM, Wallin A, Warncke K, Washington E, Waugh K, Wikoff B, Williams A, Williams J, Williams N, Willis J, Wimar Å, Winkler C, Wohlgemuth G, Wong J, Wyatt R, Yang J, Yan X, Yu L, Zhao Y, Ziegler AG
Studies
Citation
Yang J, Lernmark Å, Uusitalo UM, Lynch KF, Veijola R, Winkler C, Larsson HE, Rewers M, She JX, Ziegler AG, Simell OG, Hagopian WA, Akolkar B, Krischer JP, Vehik K, TEDDY Study Group. Prevalence of obesity was related to HLA-DQ in 2-4-year-old children at genetic risk for type 1 diabetes. Int J Obes (Lond) 2014 Dec;38(12):1491-6. Epub 2014 Apr 3.

Abstract

Body size is postulated to modulate type 1 diabetes as either a trigger of islet autoimmunity or an accelerator to clinical onset after seroconversion. As overweight and obesity continue to rise among children, the aim of this study was to determine whether human leukocyte antigen DQ (HLA-DQ) genotypes may be related to body size among children genetically at risk for type 1 diabetes.