An official website of the United States government

Publication Information

PubMed ID
Public Release Type
Journal
Publication Year
2014
Affiliation
Department of Clinical Sciences, Lund University, Skåne University Hospital SUS, Malmö, Sweden.
Authors
Abbondondolo M, Åberg S, Adams C, Agardh D, Akolkar B, Alejandrino M, Anderson SW, Andrén-Aronsson C, Ask M, Austin S, Ayres S, Barriga K, Bautista K, Baxter J, Becker D, Beyerlein A, Bingley P, Boldison J, Bonifacio E, Bourcier K, Bratrude B, Bremer J, Briese T, Broadhurst J, Brown R, Bugawan T, Burkhardt B, Butterly J, Butterworth M, Carreno G, Chandler K, Chen WM, Cilio C, Coughlin D, Crouch CC, Curnock R, Cuthbertson D, Daftary A, Dalmagro-Elias M, Davis J, Easton P, Eberhard C, Eisenbarth G, Elding Larsson H, Ericson-Hallström E, Eriksson EA, Erlich H, Erlund I, Farber E, Fiehn O, Fiske S, Foghis G, Foterek K, Fowler G, Franciscus M, Franco C, Frank N, Fransson L, Gallo D, Gardiner M, Gard T, Geoghan I, Gerardsson J, Gesualdo P, Goode J, Gowda V, Hadley D, Hagopian W, Hagopian WA, Haller M, Haller MJ, Hammar C, Hansen M, Hansson G, Hay KM, Heaney D, Henneberger L, Higgins H, Hoffman M, Hopkins D, Hummel M, Hummel S, Hyberg S, Hyöty H, Ide L, Ilonen J, Järvirova MS, Jiang N, Johansen F, Johnson SB, Jonasdottir B, Karban R, Karlsson EL, Karlsson UM, Kersting M, Ke S, Killian M, Kind T, Knip M, Knopff A, Koletzko S, Krause S, Krischer J, Krischer JP, Larsson HE, Lee HS, Lehtonen M, Leiviskä J, Lernmark Å, Lernmark B, Little RR, Liu E, Liu H, Liu S, Long A, Lönnrot M, Lynch K, Malloy J, Månsson-Martinez M, Mantymaki E, Marcovina SM, Marcus P, Markan M, Massadakis T, McCarthy C, McIndoe R, McLeod W, Melin J, Meyer A, Miao D, Mulenga D, Mykkänen J, Nanto-Salonen K, Nechtman J, Niininen T, Nilsson A, Norris J, Nyblom M, Oberste S, Onengut-Gumuscu S, Palazoglu M, Pearson J, Peplow C, Petrosino JF, Pflüger M, Pickin RR, Rahmati K, Reed C, Rewers M, Rich SS, Ridewood S, Riikonen A, Rokni S, Romo M, Roth R, Salminen I, Samper-Imaz A, Schatz D, Schenkel J, Scott E, Shankar M, Sharma A, She JX, Sibthorpe S, Silvis K, Simell B, Simell O, Simell OG, Simell T, Simell V, Sjöberg B, Sjöberg M, Skidmore J, Smith L, Smith S, Stabbert J, Steck A, Steed L, Stenius A, Stepitova V, Stock J, Strauss E, Sundvall J, Swartling U, Tamura R, TEDDY Study Group, Tennill AL, Thomas J, Toppari J, Törn C, Triplett E, Trulsson E, Uusitalo U, Varjonen E, Vehik K, Veijola R, Virtanen SM, Wallin A, Warncke K, Washington E, Waugh K, Wikoff B, Williams A, Williams J, Williams N, Wimar Å, Winkler C, Wohlgemuth G, Wong J, Wyatt R, Yang J, Yan X, Yu L, Zhao Y, Ziegler A, Ziegler AG
Studies
Citation
Elding Larsson H, Vehik K, Gesualdo P, Akolkar B, Hagopian W, Krischer J, Lernmark Å, Rewers M, Simell O, She JX, Ziegler A, Haller MJ, TEDDY Study Group. Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease. Pediatr Diabetes 2014 Mar;15(2):118-26. Epub 2013 Aug 27.

Abstract

The Environmental Determinants of Diabetes in the Young (TEDDY) study is designed to identify environmental exposures triggering islet autoimmunity and type 1 diabetes (T1D) in genetically high-risk children. We describe the first 100 participants diagnosed with T1D, hypothesizing that (i) they are diagnosed at an early stage of disease, (ii) a high proportion are diagnosed by an oral glucose tolerance test (OGTT), and (iii) risk for early T1D is related to country, population, human leukocyte antigen (HLA)-genotypes and immunological markers.