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Publication Information
Affiliation
Institute of Diabetes Research, Helmholtz Zentrum München and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Ingolstädter Landstrasse 1, 85764, Neuherberg, Germany.
Authors
Akolkar B, Bonifacio E, Briese T, Hagopian W, Hyoty H, Krischer J, Lee HS, Lernmark Å, Pflueger M, Rewers M, She JX, Simell O, TEDDY study group, Winkler C, Ziegler AG
Studies
Citation
Lee HS, Briese T, Winkler C, Rewers M, Bonifacio E, Hyoty H, Pflueger M, Simell O, She JX, Hagopian W, Lernmark Å, Akolkar B, Krischer J, Ziegler AG, TEDDY study group. Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes. Diabetologia 2013 Aug;56(8):1705-1711. Epub 2013 May 9.Abstract
Viruses are candidate causative agents in the pathogenesis of autoimmune (type 1) diabetes. We hypothesised that children with a rapid onset of type 1 diabetes may have been exposed to such agents shortly before the initiation of islet autoimmunity, possibly at high dose, and thus study of these children could help identify viruses involved in the development of autoimmune diabetes.