NIDDK Central Repository - A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study.

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NIDDK Central Repository

Publication Information

DOI

10.1089/dia.2007.0229

PubMed ID

17931054

Public Release Type

Journal

Publication Year

2007

Affiliation

Immunogenetics Laboratory and MediCity Research Laboratory, University of Turku, Finland. minna.kiviniemi@utu.fi

Authors

Hermann R, Ilonen J, Kiviniemi M, Knip M, Lövgren T, Nurmi J, Simell O, TEDDY Study Group, Veijola R, Ziegler AG

Studies

TEDDY

Citation

Kiviniemi M, Hermann R, Nurmi J, Ziegler AG, Knip M, Simell O, Veijola R, Lövgren T, Ilonen J, TEDDY Study Group. A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study. Diabetes Technol Ther 2007 Oct;9(5):460-72.

Abstract

In the TEDDY (The Environmental Determinants of Diabetes in the Young) study patient eligibility is based on the presence of some selected type 1 diabetes risk-associated human leukocyte antigen DR-DQ genotypes. A practical screening strategy was needed with efficient exclusion of ineligible patients at an early stage. Also, a simple, low-cost, and fast screening system was essential for the primary step of the risk assessment including thousands of samples.