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PubMed ID:
9679937
Public Release Type:
Journal
Publication Year: 1998
Affiliation: Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, USA.
Authors:
Buffington CA,
Wolfe SA Jr
Studies:
Interstitial Cystitis cohort study
Pain is a common feature of interstitial cystitis (IC). Although the effects of IC on sensory neuron density have been investigated, its influence on substance P receptor (SPR) numbers and function are not well known. To evaluate the role of SPR in cats with IC, we measured the affinity (Kd), numbers (Bmax), and substrate specificity of binding sites for [3H]SP in urinary bladders of healthy cats and cats suffering from IC.
