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PubMed ID:
9474229
Public Release Type:
Journal
Publication Year: 1998
Affiliation: Department of Medical Clinics, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil.
DOI:
https://doi.org/10.1016/s0022-5347(01)63833-3
Authors:
Reche Júnior A,
Buffington CA
Studies:
Interstitial Cystitis cohort study
Environmental stressors seem to play a role in exacerbation of symptoms of interstitial cystitis (IC), both in cats and in human beings. These observations suggest a role for the sympathetic nervous system in the pathophysiology of IC. To begin to assess the underlying role in IC of the pontine nucleus locus coeruleus (LC), the most important source of norepinephrine in the central nervous system, we compared the intensity of tyrosine hydroxylase immunoreactivity (THIR) in sections of LC obtained from cats with IC and from healthy cats. Cats with IC were studied during quiescent periods in an attempt to avoid the risk of flare-induced activation of the LC.
