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TONIC

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Title
PMID
PMCID
Public Release Type
Publication Year
DOI
Study Acronym
Study Network
Request ID(s)
Public Release Origin
A ranked-based approach to evaluate a surrogate marker in a small sample size setting38386359PMC10883071Journal202410.1093/biomtc/ujad035TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)23684Secondary Research
Alanine Aminotransferase as a Monitoring Biomarker in Children with Nonalcoholic Fatty Liver Disease: A Secondary Analysis Using TONIC Trial Data.29799476PMC6025615Journal201810.3390/children5060064TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)21114Secondary Research
Association Between Polypharmacy, Patient Reported Symptoms, and Quality of Life among Nonalcoholic Fatty Liver Disease Patients in the United States.Journal202210.1007/s40267-022-00957-zNAFLD Adult, PIVENS, NAFLD Pediatric, TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)23211Secondary Research
Changes in adipose tissue insulin resistance correlate with changes in ALT and lobular inflammation in children enrolled in the TONIC trialJournal2011TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)Contributing Study
Clinical Research Network launches TONIC trial for treatment of nonalcoholic fatty liver disease in children.16456401Journal200610.1097/01.mpg.0000189332.77644.1fTONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)Contributing Study
Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease29661561PMC6019181Journal201810.1016/j.jpeds.2018.02.038TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)21114Secondary Research
Effect of Polypharmacy on Health-related Quality of Life in Pediatric Patients with Nonalcoholic Fatty Liver Disease in the United States.Journal2024NAFLD Adult, TONIC, PIVENS, NAFLD PediatricNonalcoholic Steatohepatitis Clinical Research Network (NASH)23211Secondary Research
Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.21521847PMC3110082Journal201110.1001/jama.2011.520TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)Contributing Study
Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials.24759732PMC3997354Journal201410.1371/journal.pone.0095366PIVENS, TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)Contributing Study
Shorter leukocyte telomere length protects against NAFLD progression in children.37012261PMC10070244Journal202310.1038/s41598-023-31149-yTONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)22690Secondary Research
The Effect of Polypharmacy on Quality of Life in Adult Patients with Nonalcoholic Fatty Liver Disease in the United States.35064417Journal202210.1007/s11136-022-03090-6TONIC, NAFLD Pediatric, PIVENS, NAFLD AdultNonalcoholic Steatohepatitis Clinical Research Network (NASH)23211Secondary Research
The roles of type 2 diabetes and obesity in disease activity and progression of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis37933187Journal202410.1080/03007995.2023.2279676FLINT, CyNCh, NAFLD Adult, NAFLD Pediatric, PIVENS, TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)23059Secondary Research
Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.19761871PMC2936451Journal201010.1016/j.cct.2009.09.001TONICNonalcoholic Steatohepatitis Clinical Research Network (NASH)Contributing Study
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