A ranked-based approach to evaluate a surrogate marker in a small sample size setting | 38386359 | PMC10883071 | Journal | 2024 | 10.1093/biomtc/ujad035 | TONIC | 23684 | Secondary Research |
Alanine Aminotransferase as a Monitoring Biomarker in Children with Nonalcoholic Fatty Liver Disease: A Secondary Analysis Using TONIC Trial Data. | 29799476 | PMC6025615 | Journal | 2018 | 10.3390/children5060064 | TONIC | 21114 | Secondary Research |
Association Between Polypharmacy, Patient Reported Symptoms, and Quality of Life among Nonalcoholic Fatty Liver Disease Patients in the United States. | | | Journal | 2022 | 10.1007/s40267-022-00957-z | PIVENS, TONIC, NAFLD Pediatric, NAFLD Adult | 23211 | Secondary Research |
Changes in adipose tissue insulin resistance correlate with changes in ALT and lobular inflammation in children enrolled in the TONIC trial | | | Journal | 2011 | | TONIC | | Contributing Study |
Clinical Research Network launches TONIC trial for treatment of nonalcoholic fatty liver disease in children. | 16456401 | | Journal | 2006 | 10.1097/01.mpg.0000189332.77644.1f | TONIC | | Contributing Study |
Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease | 29661561 | PMC6019181 | Journal | 2018 | 10.1016/j.jpeds.2018.02.038 | TONIC | 21114 | Secondary Research |
Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. | 21521847 | PMC3110082 | Journal | 2011 | 10.1001/jama.2011.520 | TONIC | | Contributing Study |
Genetic polymorphism of cytochrome P450 4F2, vitamin E level and histological response in adults and children with nonalcoholic fatty liver disease who participated in PIVENS and TONIC clinical trials. | 24759732 | PMC3997354 | Journal | 2014 | 10.1371/journal.pone.0095366 | PIVENS, TONIC | | Contributing Study |
Shorter leukocyte telomere length protects against NAFLD progression in children. | 37012261 | PMC10070244 | Journal | 2023 | 10.1038/s41598-023-31149-y | TONIC | 22690 | Secondary Research |
The Effect of Polypharmacy on Quality of Life in Adult Patients with Nonalcoholic Fatty Liver Disease in the United States. | 35064417 | | Journal | 2022 | 10.1007/s11136-022-03090-6 | PIVENS, TONIC, NAFLD Adult, NAFLD Pediatric | 23211 | Secondary Research |
The roles of type 2 diabetes and obesity in disease activity and progression of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis | 37933187 | | Journal | 2024 | 10.1080/03007995.2023.2279676 | CyNCh, TONIC, PIVENS, FLINT, NAFLD Adult, NAFLD Pediatric | 23059 | Secondary Research |
Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. | 19761871 | PMC2936451 | Journal | 2010 | 10.1016/j.cct.2009.09.001 | TONIC | | Contributing Study |